Azithromycin reduces spontaneous and induced inflammation in ΔF508 cystic fibrosis mice

Respiratory Research

Table 1 Cell composition of the bronchoalveolar lavage fluid and enzyme markers of lung inflammation from CF and wild-type (WT) mice in the absence of induction with P aeruginosa LPS, with and without pre-treatment with azithromycin (10 mg/kg/day), by oral administration, for 4 weeks.

		Alveolar Macrophages × 10⁴/ml	Neutrophils × 10⁴/ml	MPO OD × 10^-3/second	LDH U/L
CF	AZM-	29.7 ± 4.2	2.8 ± 1.9	11.3 ± 1.2	108.7 ± 21.1
	AZM+	19.8 ± 1.5*	0.6 ± 0.4	7.7 ± 1.0*	91.8 ± 21.0
WT	AZM-	8.6 ± 1.4	0.0 ± 0.0	3.7 ± 0.7	67.6 ± 22.3
	AZM+	12.8 ± 1.5	0.0 ± 0.0	3.6 ± 0.4	70.6 ± 12.4

Values are means ± SEM for 9–13 animals per each of the 4 subgroups from pooled data obtained from two different sets of experiments. * p < 0.025 for comparison of corresponding mean value vs. that obtained for the same parameter in the same group of animal without pre-treatment with azithromycin.

ISSN: 1465-993X