Table 4 Mean of 50 KD/46 KD VASP ratio in epithelial cells according to β₂-adrenergic receptor haplotype. Specific β₂-adrenergic receptor haplotypes are shown with the mean ratio of 50/46 KD VASP for nonasthmatic normals or asthmatics having that haplotype. Asthmatics tended to have haplotype 4 which contains Arg at amino acid 16, and rarer haplotypes such as 1, 9, and 10 than nonasthmatic normals. The overall reduced phosphorylation of VASP (higher 50/46 KD ratio) in asthmatics compared to normals does not appear associated with a specific haplotype.

Normal :

Total N = 17

N = 6

N = 5

N = 3

N = 1

N = 1

N = 1

Mean 50/46 KD

.307

.408

.455

.475

.168

.491

± SEM

± 0.07

± 0.07

± 0.10

AsthmaTic :

Total N = 30

N = 2

N = 9

N = 8

N = 3

N = 1

N = 2

N = 3

N = 1

N = 1

Mean 50/46 KD

.230

.163†

.164

.147

.187

.233

.110

.094

.046

± SEM

± 0.01

± 0.04

± 0.03

± 0.07

± 0.00

± 0.02