From: Muscarinic receptor signaling in the pathophysiology of asthma and COPD
Cell type | Presence of muscarinic receptors, ChAT and/or acetylcholine | Functional effects of acetylcholine | Â |
---|---|---|---|
T lymphocyte | Muscarinic receptors (M1-M5 *) ChAT Acetylcholine | Increased cytotoxicity Cytokine production Proliferation | [2, 83, 92] |
B lymphocyte | Muscarinic receptors (M1-M5 *) ChAT Acetylcholine | Proliferation | [2, 83] |
Mast cell | Muscarinic receptors (M1) ChAT Acetylcholine | Inhibition of histamine release | [2, 136, 137] |
Neutrophil | Muscarinic receptors (M1/M2/M3) ChAT | Chemotaxis LTB4 production # | [93, 138] |
Eosinophil | Muscarinic receptors (M1) ChAT | unknown | [93, 138] |
Macrophage/monocyte | Muscarinic receptors (M1/M2/M3) ChAT Acetylcholine | LTB4 production # | [2, 83, 93] |
Bronchial epithelium | Muscarinic receptors (M1/M3) ChAT Acetylcholine | Release of monocyte, eosinophil and neutrophil chemotactic factors | [95, 96, 98] |
Airway smooth muscle | Muscarinic receptors (M2/M3) ChAT | Pro-inflammatory gene expression | [2, 8, 99] |