Skip to main content
Figure 6 | Respiratory Research

Figure 6

From: Glycyrrhizin, inhibitor of high mobility group box-1, attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling in rats

Figure 6

Effect of GLY treatment on survival rate and pulmonary inflammation in the MCT-induced pulmonary hypertension rat. (A) GLY was administered for 42 days, and rat survival was compared with the non-treated MCT group. The survival rate was 60% in the non-treated MCT group; in contrast, the survival rate was 90% in the MCT + GLY group (*p = 0.0027). (B, C) The degree of pulmonary inflammation was measured by micro-PET at 28 days post-MCT injection. The SUV of the lung field increased in the MCT group compared with the control group (*p = 0.009). GLY treatment reduced the SUV of the lung field when compared with that of the non-treated MCT group (†p = 0.018). Data are presented as means ± SEM.

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us