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Table 2 General characteristics, comorbidity and corticosteroids treatment in NCAP and CAP control groups according to macrolide containing regimens and non-macrolide regimens

From: Lung inflammatory pattern and antibiotic treatment in pneumonia

 

NCAP

CAP controls

 

Macrolide regimens α

Non-macrolide regimen β

p value*

Macrolide regimens α

Non-macrolide regimens β

p value*

Subjects, n

23

29

 

9

6

 

Age, years

60 ± 4

63 ± 3

NS

78 ± 3

70 ± 9

NS

Male/Female

12/11

19/10

NS

7/2

5/1

NS

Co-morbidity, n

      

 - Cerebrovascular disease

4(17)

7(24)

NS

3(33)

0

NS

 - Heart disease

4(17)

8(28)

NS

2(22)

1(17)

NS

 - COPD

1(4)

6(21)

NS

3(33)

4(67)

NS

Risk class of Fine

  

NS

  

NS

 I-II

7(30)

6(21)

 

0

1(17)

 

 III-V

16(70)

23(79)

 

9(100)

5(83)

 

Inhaled corticosteroid

0

2(7)

NS

1(11)

0

NS

Systemic corticosteroid

3(13)

6(21)

NS

4(44)

2(33)

NS

  1. Data are expressed as mean ± SEM or n(%). *Mann–Whitney U test and chi-square test for continuous and categorical variables, respectively.
  2. αMacrolide regimens: beta-lactam (ceftriaxone, cefotaxime or co-amoxi-clavulanate + macrolide (azithromicyn: 500 mg/24 h).
  3. βNon-macrolide regimens: fluoroquinolone (levofloxacin: 500 mg/12-24 h) in monotherapy or beta-lactam + fluoroquinolone or other regimens.
  4. NCAP: non-responders pneumonia; CAP: community-acquired pneumonia; COPD: chronic obstructive pulmonary disease; NS: non-significant. N/A: not applicable.