Table 6 Percentagea of total OPCRD patients with COPD eligible for RCTs testing combined treatmentsb (n = 36 893)
Step | Criterion for sequential selection | NCT01120691 (I + Ga) | NCT01202188 (I + G) | NCT01315249 (I + G) | NCT01709903 (I + G) | NCT01782326 (I + G) | NCT01313650 (V + Ua) | NCT01316913 (V + U) | NCT01777334 (V + U) | NCT01431287 (T + Oa) | Median |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 | FEV1 | 27.2 | 76.5 | 67.6 | 76.5 | 43.5 | 65.8 | 65.8 | 65.8 | 80.7 | 65.8 |
2 | Other inclusion criteria | 15.0 | 59.1 | 50.2 | 33.9 | 13.8 | 32.9 | 32.9 | 32.9 | 76.4 | 32.9 |
3 | COPD related exclusion criteria | 9.5 | 42.7 | 18.4 | 21.5 | 10.7 | 28.5 | 28.2 | 31.8 | 74.9 | 28.2 |
4 | Concomitant pulmonary disease | 8.4 | 38.2 | 16.7 | 19.4 | 9.4 | 25.3 | 25.1 | 27.8 | 70.9 | 25.1 |
5 | Asthma, allergic diseases and atopy | 5.4 | 24.9 | 11.4 | 14.9 | 7.0 | 20.0 | 24.4 | 27.0 | 68.7 | 20.0 |
6 | Comorbidities | 4.1 | 19.2 | 9.0 | 11.2 | 5.0 | 14.8 | 18.2 | 20.1 | 52.2 | 14.8 |
7 | Other relevant conditions | 4.0 | 18.5 | 8.9 | 11.1 | 4.8 | 13.7 | 16.7 | 18.5 | 48.9 | 13.7 |
8 | Final eligible proportion (%) eligible | 3.5 | 15.2 | 7.2 | 8.6 | 3.9 | 13.7 | 13.2 | 14.7 | 48.9 | 13.2 |