High levels of biomarkers of collagen remodeling are associated with increased mortality in COPD – results from the ECLIPSE study

Table 1 Biomarker specifications

Biomarker	Specifications	Measure	References
BGM	Biglycan degraded by MMPs	IM remodeling	[18]
C1M	Collagen type I degraded by MMPs	IM remodeling	[11]
C3A	Collagen type III degraded by ADAMTS	IM remodeling	Unpublished^a
C3M	Collagen type III degraded by MMP	IM remodeling	[12]
C4M	Collagen type IV degraded by MMPs	BM remodeling	[15]
C6M	Collagen type VI degraded by MMPs	IM remodeling	[13]
CRPM	CRP degraded by MMPs	Local chronic inflammation	[19]
ELM7	Elastin degraded by MMP-7	IM remodeling	[17]
EL-NE	Elastin degraded by neutrophil elastase	IM remodeling	[16]
Pro-C6	Collagen type VI C5 domain (released)	IM remodeling	[14]

MMP matrix metalloproteinase, ADAMTS a disintegrin and metalloproteinase with thrombospondin motifs, IM interstitial matrix, BM basement membrane, CRP C-reactive protein
^aThe C3A assay was validated following a standard protocol as described in [11]

ISSN: 1465-993X