Fig. 5

Gene expression in blood samples from patients with moderate and severe COPD between patients without ICS treatment and patients receiving ICS. a The graphs show mean and individual data from RT-PCR analysis of CD31, CD34, IL-6, Sirt1 mRNA, miR-34a, and miR126-3p expression between patients without ICS treatment (ICS-) and patients receiving ICS (ICS +) in subjects with severe COPD. We found a significant decrease in Sirt1 expression, and a tendency toward decreased CD31 and IL-6 expression in blood cells from patients receiving ICS. b The graphs show mean and individual data from RT-PCR analysis of IL-6 mRNA expression between patients without ICS treatment (ICS-) and patients receiving ICS (ICS +) in subjects with moderate and severe COPD. c A positive correlation was seen between IL-6 and Sirt1 mRNA expression among patients without ICS treatment (ICS -) in severe COPD subjects. No significant correlation was seen between IL-6 and Sirt1 mRNA expression among patients receiving ICS (ICS +) in subjects with severe COPD. Data are expressed as mean ± SD