Agonist | cAMP | Proliferation vs serum | Proliferation vs PDGF | |||
---|---|---|---|---|---|---|
pEC50 | Emax (% max) | pEC50 | Emax (% max) | pEC50 | Emax (% max) | |
Treprostinil | 6.82 ± 0.06 | 101 ± 0.58 | 6.99 ± 0.27 | 42.5 ± 5.36 | 7.53 ± 0.12 | 63.7 ± 6.39 |
MRE-269 | 6.75 ± 0.15 | 52.9 ± 4.36 | NC | NC | 6.50 ± 0.23 | 85.7 ± 7.65 |
Iloprost | 7.11 ± 0.34 | 99.5 ± 7.22 | NC | NC | NC | NC |
BMY-45778 | 7.25 ± 0.09 | 50.0 ± 4.59 | ND | ND | ND | ND |
Beraprost | 6.98 ± 0.08 | 107 ± 8.99 | ND | ND | ND | ND |
PGE2 | 7.34 ± 0.10 | 85.5 ± 8.64 | 7.04 ± 0.18 | 43.1 ± 6.14 | 8.60 ± 0.08 | 71.0 ± 3.86 |
Misoprostol | 6.97 ± 0.06 | 52.4 ± 6.23 | 6.74 ± 0.10 | 34.7 ± 0.71 | 6.13 ± 0.04 | 94.1 ± 1.59 |
Butaprost | 5.81 ± 0.16 | 8.76 ± 3.25 | 7.19 ± 0.38 | 29.1 ± 7.29 | NC | NC |
AGN-205204 | 6.62 ± 0.12 | 49.7 ± 3.84 | 6.91 ± 0.48 | 51.3 ± 8.89 | 7.45 ± 0.25 | 101 ± 3.71 |
Formoterol | 9.38 ± 0.20 | 103 ± 4.60 | 9.58 ± 0.29 | 37.2 ± 2.64 | 9.08 ± 0.72 | 70.1 ± 2.96 |
Indacaterol | 8.58 ± 0.20 | 83.3 ± 4.47 | 7.96 ± 0.35 | 47.9 ± 1.58 | 8.84 ± 0.28 | 90.3 ± 5.25 |
Salbutamol | 7.36 ± 0.34 | 68.9 ± 1.40 | 7.04 ± 0.57 | 32.4 ± 5.84 | 7.98 ± 0.17 | 69.2 ± 5.53 |
Salmeterol | 9.91 ± 0.16 | 45.8 ± 3.53 | 9.58 ± 0.14 | 37.7 ± 7.33 | 10.5 ± 0.15 | 89.2 ± 0.27 |
α-MSH | NC | NC | NC | NC | NC | NC |
NECA | 5.39 ± 0.13 | 47.3 ± 3.40 | NC | NC | 6.94 ± 0.43 | 37.8 ± 14.7 |
CGS-21680 | NC | NC | NC | NC | NC | NC |
BAY60–6583 | 6.57 ± 0.06 | 10.2 ± 2.89 | 5.30 ± 0.16 | 100 ± 0.01 | 5.30 ± 0.12 | 100 ± 0.01 |
Dopamine | 5.39 ± 0.07 | 41.2 ± 10.0 | ND | ND | 4.78 ± 0.27 | 73.5 ± 13.5 |
Forskolin | NC | NC | 5.28 ± 0.13 | 74.0 ± 6.70 | 5.98 ± 0.14 | 90.8 ± 9.12 |
IBMX | NC | NC | NC | NC | NC | NC |
Rolipram | NC | NC | NC | NC | NC | NC |