Fig. 4From: Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice)The lung volume of offspring and dams was increased by maternal consumption of a high fat diet. From 4 weeks of age, female mice were fed either a low fat diet (LFD, n = 14) or high fat diet (HFD, n = 14). Female mice were mated with male mice, first after dams were fed either diet for 12 weeks, and secondly 1 week after the first litter of offspring was tested for lung function. Offspring of both pregnancies had their lung function measured at 2 weeks of age. The dams had their lung function measured after eating the LFD or HFD for 29 weeks. In (a), thoracic lung volume; (b), specific airway resistance (SRaw); (c), specific tissue damping (SG); (d), specific tissue elastance (SH); and (e), hysteresivity (G/H) measured for offspring born to the first and second matings, and dams (respectively). Data are shown as mean + SEM, with number of mice (n)/treatment shown (*p < 0.05)Back to article page