Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice)

Table 2 Eating a high fat diet did not affect the number of pregnancies or time to confirmed pregnancy or initial pregnancy weight gain of female C57Bl/6 J mice

Outcome	LFD	HFD
First pregnancy
Confirmed pregnancies (n)	14/14	14/14
Time to confirmed pregnancy (days)	10.5 ± 0.8	10.9 ± 0.8
Weight gain - first 10 days of pregnancy (g)	4.8 ± 0.5	5.2 ± 0.6
(%)	123 ± 3	122 ± 3
Second pregnancy
Confirmed pregnancies (n)	8/14	8/14
Time to confirmed pregnancy (days)	9.8 ± 0.4	8.4 ± 0.6
Weight gain - first 10 days of pregnancy (g)	5.0 ± 0.6	5.3 ± 0.5
(%)	124 ± 3	122 ± 3

From 4 weeks of age, C57Bl/6 J female mice (n = 28) were separated into 2 treatment groups and fed either a low fat diet (LFD, n = 14) or high fat diet (HFD, n = 14). Female mice were first mated with C57Bl/6 J male mice after dams had been fed either diet for 12 weeks. Three weeks later, offspring were born. Dams were re-mated 1 week after their first litters were removed at 2 weeks of age. Data are shown as mean ± SEM

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