From: Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates
Formulation | Concentration (mg/ml) | Viscosity (20 °C) (mPa*s) | Total Output Rate (mg/min) | Mass Median Diameter (mm) | GSD | Respirable Fraction < 5 μm (%) | Nebulization time (min) (2 ml) |
---|---|---|---|---|---|---|---|
Saline 0.9% | – | ~ 1.09 | 1072 ± 225 | 4.35 ± 0.25 | 1.76 ± 0.04 | 59.89 ± 4.29 | n.d. (~ 1.8–2.0 min) |
IgG 10% | 100 | 3.2 ± 0.03 | 602 ± 88 | 3.74 ± 0.07 | 1.53 ± 0.07 | 76.87 ± 2.04 | 3 ± 0.4 |
IgG 5% | 50 | 1.77 ± 0.01 | 812 ±132 | 3.98 ± 0.09 | 1.60 ± 0.02 | 69.68 ± 2.33 | 2.2 ± 0.4 |
IgA 5% | 50 | 2.31 ± 0.01 | 700 ± 90 | 3.86 ± 0.10 | 1.57 ± 0.03 | 73.13 ± 2.97 | 2.6 ± 0.3 |
IgAM 5% | 50 | 3.74 ± 0.02 | 681 ± 38 | 3.73 ±0.11 | 1.55 ± 0.03 | 76.46 ± 3.24 | 2.4 ± 0.2 |