Table 2 Assessment of Ig stability upon nebulization by size exclusion chromatography. Ig formulations were nebulized or left untreated and then analyzed by size exclusion chromatography. Percentage of fragments, monomers, dimers, polymers and high molecular species (HMS) are reported
From: Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates
Formulation | Condition | Polymers & HMS (%) | Monomers and Dimers (%) | Fragments (%) |
|---|---|---|---|---|
IgG 10% | non-nebulized | < 1 | > 98 | < 1 |
nebulized | < 1 | > 98 | < 1 | |
IgG 5% | non-nebulized | < 1 | > 98 | 1 |
nebulized | < 1 | > 98 | < 1 | |
IgA 5% | non-nebulized | 23 | 74 | 3 |
nebulized | 23 | 74 | 3 | |
IgAM 5% | non-nebulized | 62 | 34 | 4 |
nebulized | 60 | 35 | 5 |