SEPAR IPF National Registry | INSIGHTS-IPF [17] | Finnish IPF [18] | Swedish IPF [19] | Indian IPF Ω [20] | Australian IPF [21] | EMPIRE IPF [22] | EurIPFreg [23] | |
---|---|---|---|---|---|---|---|---|
Country | Spain | Germany | Finland | Sweden | India | Australia | Czech part | Europe b |
Number of patients, n | 608 | 502 | 111 | 71 | 148 | 647 | 514 | 525 |
Males, % | 80.8 | 77.9 | 60.4 | 70.4 | 73.6 | 67.7 | 69.8 | 73.7 |
Age mean years | 70.2 | 68.7 | 73.5 | 70.0 | 64.7 | 70.9 | 67.0 | 68.1 |
BMI mean Kg/m2 | 28.2 | 27.6 | 28.1 | 27.0 | – | 28.7 | 28.7 | 27.2 |
Ex-smoker, % | 63.7 | 60.2 | 45.9 | 56.4 | – | 71.7 | – | 65.4 |
6MWD, mean m | 423.5 | 267.6 | – | – | 420 | 388 | ||
FVC, mean % of predicted | 77.6 | 72.2 | 80.4 | 72.3 | 57.5 | 81.0 | 80.0 | 68.4 |
DLCO, mean % of predicted | 48.5 | 35.5 | 57.3 | 52.1 | – | 48.4 | 45.6 | 42.1 |
Symptoms indicative of IPF at diagnosis, % | ||||||||
Dyspnoea | 84.7 | 85.9 | 44.7 a | – | – | – | – | 90.1 |
Inspiratory bibasilar crackles | 89.6 | 79.0 | – | – | – | – | – | 95.5 |
Cough | 62.8 | 74.9 | 46.6 a | – | – | – | – | 53.2 |
Procedures for definitive diagnosis, % | ||||||||
HRCT | 99.2 | 90.2 | – | 72 | – | – | – | – |
Surgical lung biopsy | 26.5 | 34.1 | – | 14 | – | – | – | 32 → 8 c |
Multidisciplinary discussion | 23.8 | 21.8 | – | 20 | – | – | – | – |