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Table 3 Incidence Rate Ratio (95% Confidence Intervals) for PPCs by DLco Status

From: Impact of diffusing lung capacity before and after neoadjuvant concurrent chemoradiation on postoperative pulmonary complications among patients with stage IIIA/N2 non-small-cell lung cancer

 

Crude IRR (95% CI)

Model 1 IRR (95% CI)

Model 2 IRR (95% CI)

DLco at diagnosis

 Normal (N = 165)

Reference

Reference

Reference

 Low (N = 156)

2.42 (1.58, 3.72)

2.14 (1.38, 3.30)

2.14 (1.36, 3.36)

P value

< .001

.001

.001

Dlco Before And After CCRT

 NN: Normal → Normal (N = 76)

Reference

Reference

Reference

 NL: Normal → Low (N = 89)

2.07 (0.91, 4.74)

2.01 (0.88, 4.60)

2.05 (0.89, 4.73)

 LL: Low → Low (N = 75)

3.33 (1.52, 7.30)

3.00 (1.34, 6.73)

3.03 (1.34, 6.89)

 LVL: Low → Very Low (N=81)

4.29 (2.01, 9.14)

3.63 (1.67, 7.88)

3.78 (1.68, 8.49)

P for trends

< .001

.004

.005

  1. CCRT concurrent chemoradiotherapy; CI confidence intervals; DLco diffusing capacity of the lung for carbon monoxide; FEV1 forced expiratory volume in one second; FVC forced vital capacity; IRR incidence rate ratio; PPC postoperative pulmonary complication
  2. Model 1: Adjusted for age, sex and type of surgery (lobectomy vs others)
  3. Model 2: Further adjusted for post CCRT airflow limitation (FEV1 / FVC < 70%), and post CCRT hemoglobin