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Table 4 Crude and adjusted hazard ratios (HR) of 5-year mortality from time since IPF diagnosis for the original GAP stages and with redefined cut-points, as estimated by the Cox proportional hazards model

From: The European MultiPartner IPF registry (EMPIRE): validating long-term prognostic factors in idiopathic pulmonary fibrosis

 

Number (%)

Crude HR (95% CI)

Adjusted HRa (95% CI)

GAP stage

 I

772 (47.7)

Reference

Reference

 II

710 (43.8)

3.32 (2.59–4.26)

2.89 (2.25–3.73)

 III

138 (8.5)

5.12 (3.60–7.28)

3.97 (2.76–5.71)

GAP stage with redefined cut-points

 I

488 (30.1)

Reference

Reference

 II

485 (29.9)

3.22 (1.97–4.31)

2.66 (1.80–3.94)

 III

647 (39.9)

6.92 (4.86–9.85)

5.79 (4.03–8.31)

  1. aAdjusted for pulmonary hypertension, lung cancer and long-term oxygen therapy, concordance index = 0.81 and 0.77 respectively
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Respiratory Research

ISSN: 1465-993X

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