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Fig. 1 | Respiratory Research

Fig. 1

From: Cell-specific toxicity of short-term JUUL aerosol exposure to human bronchial epithelial cells and murine macrophages exposed at the air–liquid interface

Fig. 1

JUUL crème brûlée-flavored aerosols are cytotoxic to BEAS-2B cells. Short-term ALI exposure to JUUL causes (a) alterations in cellular surface morphology compared to air controls, as BEAS-2B cells typically have a cobblestone-like appearance as indicated by SEM. Images were taken at 10,000× and 15,000× magnification. b JUUL causes a significant decrease in cell viability (n = 8 replicates per group; combined data from three independent experiments each performed in duplicate or triplicate); c a significant increase in extracellular release of LDH (n = 3 per group); d an increase in extracellular ROS species production (n = 3 per group); e an increase in NO species production in BEAS-2B cells compared to air controls (n = 3 per group); f and an increase in TEER (n = 3 per group). The student’s t-test was used to compare results between JUUL aerosol-exposed cells and air controls. Data represent the mean ± SEM, *p < 0.05

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Respiratory Research

ISSN: 1465-993X

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