Table 1 The characteristics of the included preclinical studies
Reference | Animal, gender | Injury model | MSCs source | Type of stem cell derived therapy | Time of assessment |
|---|---|---|---|---|---|
Amir Varkouhi [19] | SD rats | E. coli (5. 109 CFUs), IT | Human UC MSC | Extracellular vesicles, 100*106/kg, IV | 48 h after E. coli instillation |
Antoine Monsel [20] | Male C57BL/6 mice | E. coli (2 or 3 × 106 CFUs), IT | Human BM MSC | Microvesicles, 1*106 cells/10 ul, IT/IV | 18, 24, or 72 h after modeling |
Chen Wenxia [21] | Male SD rats | BLM (4 mg/kg), IT | Human WJ MSC | Microvesicles, IT | 48 h or 1 week after bleomycin treatment |
Huang Ruoqiong [22] | C57BL/6 mice | LPS (4 mg/kg), IT | Human AD MSC | MSC extracellular vesicles, 100 μg/200 ul | 48 h after LPS insult |
James Devaney [23] | Male SD rats | E. coli (2 × 109), IT | Human BM MSC | hMSC-CM | 48 h after E. coli instillation |
Johnatas Silva [24] | C57BL/6 mice | LPS 2 mg/kg, IT | Mouse BM MSC | MSC extracellular vesicles, 1*105 cells, IV | 24 h after MSCs, or EV administration |
Lavinia Ionescu [25] | Male C57BL/6 Mice | 4 mg/kg LPS | Mouse BM MSC | MSC CM 250,000 cells/30 μl, IT | 48 h post-LPS insult |
Li Qing-Chun [26] | Male SD rats | Chest trauma induced ALI | Rat BM MSC | MSC-derived exosomes, 25 ug/100 μl, IV | 7 days after modeling |
Liu Jianpei [27] | Male SD rats | Intestinal IR induced ALI | Rat BM MSC | MSC-derived exosomes, 5–10 ug/500 μl, IV | 20 h after modeling |
Mahesh Khatri [28] | White-Duroc pigs | H1N1, 5 × 106 TCID50 per pig | Porcine BM MSC | MSC-derived extracellular vesicles, 10 μg/ml, IT | 1 and 3 days post-infection |
Mairead Hayes [29] | Male SD rats | Ventilator induced lung injury | Rat BM MSC | MSC-CM, 4 × 106 cells/500 μl, IV | 4 h following VILI induction |
Peng Chung-Kan [30] | Male SD rats | IR induced ALI | RAT NC SCs | NCSCs-CM, 5 × 106 cells/250 μl, IV | 90 min after modeling |
Tang Xiaodan [31] | Male C57BL/6 mice | LPS (4 mg/kg), IT | Human BM MSC | MSC microvesicles, 2 × 106 cells/30 μl, IV | 48 h after microvesicles injection |
Vincent Su [32] | Male C57BL/6 mice | LPS (5 mg/kg), IT | Mouse MSC | MSC-CM, 200 μl, IV | 24 h after MSC-CM treatment |
Xu Ning [33] | Male SD rats | Phosgene (8.33 g/m3), inhaled | Rat BM MSC | MSC-derived exosomes, 50 mL, IT | 6, 24, and 48 h post-exposure |
Yi Xiaomeng [34] | C57BL/6 mice | LPS (1 mg/kg), IT | Mouse BM MSC | MSC-derived exosomes (30 μL), IV | 24 h after LPS induction |
Zhu Ying-gang [35] | Male C57BL/6 mice | LPS (4 mg/kg), IT | Human MSC | MSC microvesicles, 1.5 × 106 cells/ 15 μl | 48 h after microvesicles injection |