Skip to main content
Fig. 5 | Respiratory Research

Fig. 5

From: FFAR1 activation attenuates histamine-induced myosin light chain phosphorylation and cortical tension development in human airway smooth muscle cells

Fig. 5

Conceptual model of FFAR1 agonist effect on some steps of EC coupling and cell shortening in HASM cells. The activation of FFAR1 receptors by agonists, GW9508 or TAK875, leads to the attenuation of MLC phosphorylation and cell shortening in HASM cells. The precise molecular mechanisms remain unknown but are independent of cAMP generation, pAKT inactivation, and MYPT1 phosphorylation. (blue font: no change by FFAR1 agonists; red font: attenuated by FFAR1 agonists)

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us