Fig. 2
From: Aerosol drug delivery to spontaneously-breathing preterm neonates: lessons learned
Intrinsic and extrinsic factors influencing aerosol drug delivery in premature infants. The figure depicts two possible scenarios: (1) nebulizer positioned in the inspiratory limb of a standard constant flow ventilator (top); this nebulizer positioning could also be applied to bubble Continuous Positive Airway Pressure (CPAP) and variable flow drivers, and to High Flow Nasal Cannula (HFNC); (2) nebulizer positioned between the Y piece and the patient interface in a standard constant flow ventilator (bottom); this nebulizer positioning could be compatible with bubble CPAP but not with variable flow drivers nor HFNC