From: Aerosol drug delivery to spontaneously-breathing preterm neonates: lessons learned
Study (author—year) | Patients (GA in weeks and BW in Kg) | Nebulizer type | Ventilation | Nebulizer position | Interface | Drug | Particle size |
---|---|---|---|---|---|---|---|
Jorch et al. 1997 | 31 (28–35) BW N.A: | Jet | Bubble CPAP | Y piece | Nasopharyngeal tube | Animal derived surfactant Bovactant |  < 4 µm (98% of the particles) |
Arroe et al. 1998 | 23–36 BW N.A | Jet | nCPAP | Inspiratory limb | Unknown | Animal derived surfactant—colfosceril palmitate | N.A |
Berggren et al. 2000 | 27–34 1.62 (1.01–2.37) | Jet | Infant flow | inspiratory limb | Prongs | Animal derived surfactant – |  < 2 µm |
Finer et al | 28–32 1.50 (1.00–2.30) | Vibrating-membrane | Several NIV types | Y piece | Prongs | Synthetic surfactant—KL4 | N.A |
Guardia et al. 2018 | 29–34 BW unknown | Capillary Aerosol Generator (CAG) | Bubble CPAP | Y piece | Affectair® | Synthetic surfactant—KL4 | N.A |
Sood et al. 2019 | 24–36 0.79–2.25 | Jet | nCPAP/nIPPV unspecified driver | Inspiratory Limb | N.A | Animal derived surfactant—Beractant | N.A |
Minocchieri et al. 2019 | 29–33 1.56 (mean) | Vibrating-membrane | Bubble CPAP | Y piece | facial mask (with hole) | Animal derived surfactant—Poractant alfa | 2.6 µm (MMD) |
Cummings et al. 2020 | 23–41 1.96 (0.59–4.80) | Jet | Several NIV types | Inside the mouth | Pacifier adapter | Animal derived surfactant—Calfactant | N.A |