“Can do, don’t do” are not the lazy ones: a longitudinal study on physical functioning in patients with COPD

Sievi, Noriane A.; Brack, Thomas; Brutsche, Martin H.; Frey, Martin; Irani, Sarosh; Leuppi, Jörg D.; Thurnheer, Robert; Kohler, Malcolm; Clarenbach, Christian F.

doi:10.1186/s12931-020-1290-9

Respiratory Research

Table 4 Comparison of median annual change in clinical characteristics between changing groups

From: “Can do, don’t do” are not the lazy ones: a longitudinal study on physical functioning in patients with COPD

Dependent variable	Remainer N = 100	Decliner N = 29	Improver N = 20	Waverer N = 24	P-value
Median annual change BMI, kg/m²	−0.08 (− 0.75/0.66)	− 0.03 (− 1.09/0.46)	0.01 (− 0.93/1.02)	0 (− 0.71/0.35)	0.740
Median annual change Waist/Hip ratio	0.01 (− 0.03/0.04)	0.01 (− 0.01/0.03)	−0.01 (− 0.03/0.02)	0 (− 0.04/0.02)	0.094
Median annual change mMRC score	0 (0/1)	0 (0/1)	0 (− 1/0)	0 (0/1)	0.210
Median annual change CAT score	1 (−3/3)	2 (−2/4)	−1 (− 5/3)^†	1 (− 2/3)^‡	0.042
Median annual change Anxiety score	0 (− 2/1)	0 (− 1/1)	0 (− 2/1)	0 (− 1/2)	0.330
Median annual change Depression score	0 (−2/1)	0 (− 1/2)	− 1 (− 2/0) ^†	0.5 (− 1.0/1.5)	0.045
Median annual change FEV₁, % pred.	0 (−4/6)	0 (− 3/5)	3 (− 4/6)	− 2 (− 6/1)*	0.046
Median annual change RV/TLC, %	0 (−5/5)	1 (− 5/5)	0 (− 3.0/2.5)	2.5 (− 2.5/6.0)	0.180
Median annual change TLco, % pred.	−2 (− 6.7/4.0)	− 3 (−9/2)	0 (− 6/6)	− 1.0 (− 7.0/5.0)	0.400
Median annual change PaO₂, kPa	0.1 (− 0.7/0.6)	−0.21 (− 0.69/0.60)	−0.20 (− 0.82/0.56)	0.08 (− 0.82/0.75)	0.840
Median annual change PaCO_2, kPa	0 (− 0.31/0.23)	0.01 (− 0.27/0.20)	−0.10 (− 0.29/0.14)	0.02 (− 0.17/0.42)	0.450
Median annual change SaO_2, %	0 (− 1.1/1.2)	0.1 (− 1.5/1.0)	−0.2 (− 1.5/1.0)	0 (− 1/1)	0.860
Median annual change Number of comorbidities	0 (0/0)	0 (0/1)	0 (0/1)	0 (0/0)	0.100
Median annual change Exacerbations in the previous year, N	0 (− 1/0)	0 (− 1/1)	0 (−0.5/0.0)	0 (− 1/1)	0.850
Median annual change Severe exacerbations in the previous year, N	0 (0/0)	0 (0/0)	0 (0/0)	0 (0/0)	0.810
Median annual change 6MWD, m	0 (− 30/30)	−25 (− 60.0/28.7)	11 (− 18/57.5)^†	0 (−75/35)	0.019
Median annual change 6MWD, % pred.	1.5 (− 3.0/10.0)	0 (−11/7)	9.5 (−2/20)	1 (− 14/14)^‡	0.005
Median annual change SpO₂ after 6MWT, %	0 (−3/3)	−1 (− 3/2)	0 (− 3/2)	−1 (− 5/4)	0.540
Median annual change Steps per day, N	− 298 (− 1418/566)	− 1202 (− 2926/− 348)*	− 192 (− 1393/1809)^†	− 761 (− 1870/665)	< 0.001

Values are median (25%/75% quartiles). *p < 0.05 vs “remainer”; ^†p < 0.05 vs “worsener”; ^‡p < 0.005 vs “improver”

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ISSN: 1465-993X

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