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Table 1 Baseline characteristics of GOLD group B patients according to FEV1 level

From: Dual versus monotherapy with bronchodilators in GOLD group B COPD patients according to baseline FEV1 level: a patient-level pooled analysis of phase-3 randomized clinical trials

 

All

GOLD III/IV

GOLD I/II

Number of patients

14449

8043

6406

Age

64.7 ± 8.6

64.7 ± 8.4

64.6 ± 8.9

Male

9960 (68.9)

5821 (72.4)

4139 (64.6)

Current smoker

6384 (44.2

3455 (43.0)

2929 (45.7)

Smoking pack-years

46.2 ± 22.2

44.3 ± 22.2

48.6 ± 22.0

Body mass index

26.8 ± 5.8

26.3 ± 5.8

27.4 ± 5.8

FEV1, L

1.2 ± 0.5

1.0 ± 0.3

1.5 ± 0.4

FEV1, %pred

43.8 ± 13.5

35.1 ± 9.3

54.6 ± 9.2

No of exacerbation in the preceding year

 0

11,778 (81.5)

6471 (80.5)

5307 (82.8)

 1

2671 (18.5)

1572 (19.5)

1099 (17.2)

Treatment

 LABA/LAMA

   

  Tiotropium/olodaterol

4528 (31.3)

2510 (31.2)

2018 (31.5)

  Umeclidinium/vilanterol

1487 (10.3)

796 (9.9)

691 (10.8)

  Glycopyrronium/indacaterol

791 (5.5)

492 (6.1)

299 (4.7)

 LAMA

   

  Tiotropium

4869 (33.7)

2651 (33.0)

2218 (34.6)

  Glycopyrronium

469 (3.2)

298 (3.7)

171 (2.7)

  Umeclidinium

522 (3.6)

289 (3.6)

233 (3.6)

 LABA

   

  Indacaterol

624 (4.3)

411 (5.1)

213 (3.3)

  Olodaterol

658 (4.6)

331 (4.1)

327 (5.1)

  Vilanterol

501 (3.5)

265 (3.3)

236 (3.7)

  1. Data are presented as means ± SD or number (%)
  2. FEV1 forced expiratory volume at 1 s, GOLD Global initiative for Chronic Obstructive Lung Disease, LABA long-acting beta-2 agonist, LAMA long-acting muscarinic antagonist; %pred. % of the predicted value