From: Frequency and functional translation of low muscle mass in overweight and obese patients with COPD
BMI group | Normal weight (n=206) | Overweight (n=157) | Obese (n=106) | |||
---|---|---|---|---|---|---|
FFMI group | Normal (n=88) | Low (n=118) | Normal (n=66) | Low (n=91) | Normal (n=61) | Low (n=45) |
Subjects, % males | 49.0 | 52.5 | 50.0 | 67.0* | 44.3 | 66.7* |
Age, y | 64 ± 10 | 64 ± 8 | 65 ± 9 | 65 ± 10 | 64 ± 8 | 64 ± 9 |
BMI, kg m-2 | 22.3 ± 1.8 | 21.6 ± 1.7†| 27.7 ± 1.5 | 27.0 ± 1.2†| 34.4 ± 2.9 | 31.7 ± 1.8# |
FFMI, kg m-2 | 17.2 [15.2–18.0] | 14.5 [13.8–16.3]# | 19.0 [16.4–19.6] | 17.1 [15.5–18.2]# | 20.4 [18.6–21.8] | 19.1 [16.5–20.1]# |
FEV1, l | 1.10 [0.83–1.44] | 0.92 [0.68–1.41] | 1.33 [0.96–1.90] | 1.13 [0.77–1.72] | 1.32 [0.99–1.74] | 1.45 [1.04–1.92] |
FEV1, %pred | 44.5 [34–55.6] | 37.3 [27.4–51.1]†| 55.6 [41.9–69.4] | 41.0 [32.0–65.7]* | 56.0 [41.4–70.3] | 53.5 [42.6–63.2] |
FEV1/FVC, % | 32.6 [27.8–41.3] | 30.8 [25.2–41.2] | 40.3 [32.0–48.2] | 33.0 [25.6–44.7]* | 44 [34.7–53.4] | 41.6 [33.5–49.2] |
TLCO, %pred | 45.5 [37–57.8] | 40.3 [32.0–48.5]†| 46.6 [38.0–63.0] | 48.1 [40.9–61.1] | 57.3 [49.5–68.8] | 50.8 [42.0–60.1]* |
mMRC, % grade ≥ 2 | 70.4 | 87.3†| 81.8 | 75.8 | 86.7 | 82.2 |
6MWD, m | 458 ± 121 | 410 ± 122†| 434 ± 118 | 414 ± 126 | 402 ± 108 | 430 ± 118 |
6MWD, %pred | 70 ±17 | 62 ± 18# | 70 ± 17 | 67 ±17 | 70 ± 17 | 69 ± 16 |
Wmax, W | 63 [49–87] | 53 [41–68]†| 69 [54–97] | 64 [48–83] | 66 [55–86] | 75 [54–97] |
Wmax, %pred | 52 [38–73] | 42 [31–61]†| 55 [44–76] | 48 [37–64]* | 59 [41–91] | 53 [43–65] |
VO2max, ml m-1 | 998 [805–1234] | 811 [661–978]# | 1108 [872– 1349] | 1088 [900–1291] | 1126 [892–1368] | 1267 [974–1542] |
VO2max, %pred | 57 [47–78] | 50 [36–73]* | 67 [51–86] | 58 [48–77] | 81 [55–112] | 64 [54–75]* |
CWRT, s | 267 [184–351] | 190 [149–269]# | 250 [173–343] | 218 [176–302] | 243 [172–445] | 254 [171–410] |
Quadriceps PT, Nm | 87 ± 26 | 77 ± 29†| 105 ± 37 | 95 ± 32 | 107 ± 38 | 108 ± 42 |
Quadriceps PT, %pred | 64 ± 17 | 55 ± 14# | 75 ± 17 | 65 ± 18†| 79 ± 15 | 72 ± 21* |
SGRQ Total score, pts | 59 [39–75] | 63 [50–75] | 62 [49–73] | 63 [49–73] | 68 [57–75] | 63 [52–73] |
HADS Anxiety score, pts | 7 [4–11] | 6 [4–11] | 8 [5–13] | 6 [4–10] | 7 [5–12] | 8 [4–12] |
HADS Depression score, pts | 7 [3–11] | 6 [3–10] | 7 [4–11] | 7 [4–10] | 8 [5–10] | 6 [4–11] |
ASMI, kg m-2 | 6.58 ± 0.80 | 5.73 ± 0.77* | 7.18 ± 1.06 | 6.67 ± 0.91* | 7.98 ± 1.13 | 7.50 ± 1.10* |
Lumbar spine, T-score | − 1.29 ± 1.38 | − 1.09 ± 1.69 | − 0.74 ± 1.37 | − 0.99 ± 1.66 | − 0.68 ± 1.27 | − 0.87 ± 1.64 |
Hip, T-score | − 1.56 ± 1.00 | − 1.86 ± 0.95* | − 1.69 ±0.90 | − 1.67 ± 1.00 | − 1.15 ± 1.06 | − 1.19 ± 0.91 |