Copeptin, pro-atrial natriuretic peptide and pro-adrenomedullin as markers of hypoxic stress in patients with obstructive sleep apnea—a prospective intervention study

Table 5 Differences in copeptin, proANP and proADM levels in patients with OSA between different visits

Paired comparison	Number of pairs	Mean difference ± SD of the difference	p-value (Wilcoxon signed rank test)
Copeptin baseline vs 12 h CPAP	82	− 0.59 ± 2.98	0.139
Copeptin baseline vs 1 month CPAP	101	− 0.02 ± 4.13	0.551
Copeptin baseline vs 6 months CPAP	70	0.44 ± 4.60	0.428
proADM baseline vs 12 h CPAP	82	0.01 ± 0.08	0.114
proADM baseline vs 1 month CPAP	102	0.03 ± 0.62	< 0.001
proADM baseline vs 6 months CPAP	72	− 0.04 ± 0.12	0.020
proANP baseline vs 12 h CPAP	82	− 7.19 ± 19.18	< 0.001
proANP baseline vs 1 month CPAP	103	1.68 ± 27.10	0.504
proANP baseline vs 6 months CPAP	72	2.82 ± 30.95	0.277

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