Fig. 7
From: Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice
HGF and VEGF levels in BAL fluid of IL-33−/− mice following treatment with rIL-33. The IL-33−/− mice received intraperitoneal injection of rIL-33 or PBS on day 0 following instillation of PBS or PPE. BAL were performed on day 2, and levels of HGF and VEGF in BAL fluid were measured as described in the Materials and Methods. a HGF levels. b VEGF levels. Data are shown as the mean ± SEM (n = 5–8 in each group). IL-33−/− PBS PBS: PBS-instilled IL-33−/− mice treated with PBS. IL-33−/− PPE PBS: PPE-instilled IL-33−/− mice treated with PBS. IL-33−/− PPE rIL-33: PPE-instilled IL-33−/− mice treated with rIL-33. *P < 0.05 compared to IL-33−/− PBS PBS. #P < 0.05 compared to IL-33−/− PPE PBS