Table 4 History of exacerbations in FASE-CPHG severe asthma clusters
Cluster 1 Early onset atopic (N = 690) | Cluster 2 Obese (N = 153) | Cluster 3 Late-onset (N = 299) | Cluster 4 Eosinophilic (N = 143) | Cluster 5 Aspirin-sensitivity (N = 139) | Patients analysed n = 1424 | p | ||
|---|---|---|---|---|---|---|---|---|
More than 2 exacerbations | Yes | 442 (64.1%) | 101 (66%) | 185 (61.9%) | 97 (67.8%) | 100 (71.9%) | 925(65%) | 0.26 |
Number of exacerbations with increased of OCS or ICS | Means (± sd) | 2.6 (± 3.2) | 2.6 (± 3) | 2.2 (± 2.6) | 2.9 (± 3.6) | 2.9 (± 3.1) | 2.5 (± 3.1) | 0.03 |
Median | 2 | 2 | 1 | 2 | 2 | 2 | ||
Min–Max | 0–20 | 0–16 | 0–15 | 0–20 | 0–20 | 0–20 | ||
Number of hospitalizations during the 12 past months | Means (± sd) | 0.4 (± 1.2) | 1 (± 1.8) | 0.6 (± 1.3) | 0.4 (± 1.5) | 0.4 (± 1) | 0.5 (± 1.3) | < 0.0001 |
Min–Max | 0–12 | 0–12 | 0–12 | 0–15 | 0–6 | 0–15 | ||
Number of emergency visits during the 12 past months | Means (± sd) | 0.6 (± 1.7) | 0.9 (± 2.1) | 0.6 (± 1.5) | 0.5 (± 1.8) | 0.5 (± 1.1) | 0.6 (± 1.7) | 0.04 |
Min–Max | 0–20 | 0–15 | 0–12 | 0–17 | 0–6 | 0–20 | ||
Number of medical visits during the 12 past months | Means (± sd) | 2.6 (± 3.1) | 2.8 (± 3.5) | 2.2 (± 2.5) | 3.1 (± 4) | 2.9 (± 3.2) | 2.6 (± 3.1) | 0.19 |
Median | 2 | 2 | 2 | 2 | 2 | 2 | ||
Min–Max | 0–20 | 0–20 | 0–12 | 0–20 | 0–20 | 0–20 | ||
Absenteism related to asthma during the 12 past months | Yes | 113 (16.4%) | 15 (9.8%) | 24 (8%) | 16 (11.2%) | 21 (15.1%) | 189 (13.3%)) | < 0.0001 |