From: Acute exacerbation of fibrotic hypersensitivity pneumonitis: incidence and outcomes
Characteristics | RD | No RD | ||
---|---|---|---|---|
Total | AE | No AE | ||
Patients | 33 | 18 | 15 | 68 |
Age, years | 65.0 [54.5;70.0]† | 62.5 [53.5;70.3] | 59.0 [54.0;66.0] | 62.0 [50.5;67.0] |
Female sex | 21 (63.6) | 10 (55.6) | 11 (73.3) | 40 (58.8) |
BMI, kg/m2 | 23.6 [20.4;26.8]† | 24.3 [21.9;26.8] | 25.5 [23.4;28.0] | 24.4 [22.7;27.1] |
Smoking | ||||
Ever smoker | 11 (33.3) | 7 (38.9) | 4 (26.7) | 27 (39.7) |
Smoking amount, pack-years | 30.0 [15.0;35.0] | 20.0 [15.0;30.0] | 35.0 [9.1;35.0] | 30 [12.5;45.0] |
Positive history of exposure to antigen | 27 (81.8) | 15 (83.3) | 12 (80.0) | 58 (85.3) |
Pulmonary function test (%pred.) | ||||
FVC | 63.8 ± 21.9† | 67.7 ± 23.4 | 59.2 ± 19.6† | 74.8 ± 14.0 |
DLCO | 50.8 ± 18.3† | 50.5 ± 21.7† | 51.2 ± 14.3† | 64.6 ± 14.4 |
TLC | 68.0 ± 16.6† | 71.9 ± 18.9 | 63.9 ± 13.3† | 76.2 ± 10.8 |
6 min-walk test | ||||
Distance, m | 405.0 [330.0;476.5]† | 400.0 [287.5;476.3] | 460.0 [404.0;490.0] | 460.0 [405.0;500.0] |
Lowest saturation, % | 91.0 [87.5;94.0]† | 90.0 [87.8;93.3] | 92.0 [88.0;95.0] | 93.0 [90.0;95.0] |
BALF analysis | ||||
Total WBC, /μL | 205.0 [130.0;335.0] | 180.0 [132.5;252.5] | 120.0 [80.0;275.0] | 180.0 [115.0;340.0] |
Neutrophil, % | 4.0 [1.3;6.8] | 4.0 [1.0;6.8] | 5.0 [1.0;10.0] | 4.0 [1.5;6.5] |
Lymphocyte, % | 18.0 [13.0;47.0] | 17.5 [8.5;30.5] | 31.0 [15.0;59.5] | 18.0 [11.0;32.5] |
Lympho-dominance (lymphocyte > 20%) | 11 (33.3) | 5 (27.8) | 6 (40.0) | 31 (45.6) |
UIP-like pattern on HRCT | 20 (60.6) | 15 (83.3)*,† | 5 (33.3) | 36 (52.9) |
Treatment | ||||
No treatment | 0 (0.0) | 0 (0.0) | 0 (0.0) | 10 (14.7) |
Corticosteroid ± immunosuppressants | 33 (100.0) | 18 (100.0) | 15 (100.0) | 58 (85.3) |