Fig. 4

PCTR1 regulates HPA and EXT-1 expression in LPS- triggered sepsis in mice. a–e Mice were treated with LPS (10 mg/kg) with or without PCTR1 (100 ng/mouse) for 6 h. The levels of HPA, EXT-1, SIRT1 and p65 in the lung tissue were quantified by western blot. f–h BOC-2 (ALX receptor inhibitor, 600 ng/kg) or EX527 (SIRT1 inhibitor, 10 mg/kg) or BAY11-7082 (NF-κB inhibitor, 20 mg/kg) was injected 1 h followed by LPS (10 mg/kg) with or without PCTR1 (100 ng/mouse). The protein levels of HPA and EXT-1 were measured by western blot. *P < .05, **P < .01 relative to the CONTROL group, ^# P < .05, ^## P < .01 relative to the LPS group, ^&P < .05, relative to the LPS + PCTR1 group. n = 6