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Fig. 1 | Respiratory Research

Fig. 1

From: The impact of fluid status and decremental PEEP strategy on cardiac function and lung and kidney damage in mild-moderate experimental acute respiratory distress syndrome

Fig. 1

Protocol (A) and timeline representation of the experimental protocol (B). Arterial blood gases and echocardiography were evaluated at BASELINE and FINAL. BGA blood gas analysis; ECHO echocardiography; FDA functional data acquisition; FiO2 fraction of inspired oxygen; ZEEP zero end-expiratory pressure; PEEP positive end-expiratory pressure; VT tidal volume. Twenty-four hours after intratracheal administration of Escherichia coli lipopolysaccharide, rats received standard (10 mL/kg/h, NORMO) or high (30 mL/kg/h, HIGH) volume of Ringer’s lactate. For 30 min, all rats, regardless of fluid status, were mechanically ventilated with VT = 6 mL/kg and PEEP = 9 cmH2O, and then randomized to the following groups: abrupt PEEP decrease from 9 to 3 cmH2O (FAST) or gradual PEEP decrease (0.2 cmH2O/min) from 9 to 3 cmH2O (SLOW) for 30 min

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Respiratory Research

ISSN: 1465-993X

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