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Table 4 Association between patient characteristics at enrollment and respiratory-related hospitalization

From: Hospitalizations in patients with idiopathic pulmonary fibrosis

 

Univariable model

Multivariable model

Parsimonious model

HR (95% CI)

p-value

HR (95% CI)

p-value

HR (95% CI)

p-value

Female

1.12 (0.87, 1.44)

0.374

1.24 (0.95, 1.61)

0.124

  

Age

 

< 0.001

 

< 0.001

 

< 0.001

 < 62 years, per 5-year increase

0.62 (0.50, 0.77)

 < 0.001

0.73 (0.58, 0.91)

0.005

0.68 (0.55, 0.84)

< 0.001

 ≥ 62 years, per 5-year increase

0.99 (0.90, 1.09)

0.810

0.91 (0.82, 1.01)

0.068

0.92 (0.83, 1.01)

0.085

Hispanic/Latino ethnicity

2.21 (1.34, 3.66)

0.002

1.43 (0.84, 2.45)

0.189

  

Body mass index, per 1-point increase

0.98 (0.96, 1.00)

0.070

0.95 (0.93, 0.98)

< 0.001

0.96 (0.93, 0.98)

< 0.001

Current/former smoker

1.01 (0.79, 1.29)

0.927

1.04 (0.80, 1.36)

0.763

  

Private insurance

1.00 (0.79, 1.27)

0.987

0.95 (0.72, 1.24)

0.689

  

Diagnostic criteria of definite IPFa

1.06 (0.83, 1.35)

0.645

1.10 (0.86, 1.42)

0.440

  

FVC % predicted, per absolute 10% increase

0.82 (0.76, 0.89)

< 0.001

0.93 (0.85, 1.01)

0.080

0.90 (0.83, 0.97)

0.005

DLco % predicted, per absolute 10% increase

0.75 (0.69, 0.83)

< 0.001

0.90 (0.80, 1.00)

0.057

  

Oxygen use at rest

2.88 (2.24, 3.70)

< 0.001

2.32 (1.65, 3.25)

< 0.001

2.85 (2.18, 3.72)

< 0.001

Oxygen use with activity

2.31 (1.84, 2.91)

< 0.001

1.32 (0.96, 1.80)

0.087

  

History of coronary artery disease or congestive heart failure

0.83 (0.66, 1.06)

0.133

0.87 (0.67, 1.13)

0.300

  

History of pulmonary hypertension

2.37 (1.63, 3.43)

< 0.001

1.69 (1.10, 2.60)

0.016

2.02 (1.37, 2.96)

< 0.001

History of emphysema

1.11 (0.80, 1.55)

0.530

0.79 (0.54, 1.15)

0.216

  

History of sleep apnea

1.00 (0.78, 1.28)

0.989

1.19 (0.90, 1.57)

0.221

  

Hospitalization in 12 months prior to enrollment

1.17 (0.91, 1.50)

0.221

0.91 (0.69, 1.20)

0.501

  
  1. Multivariable model included all the covariates listed. Parsimonious model included covariates selected after performing backwards selection on the multivariable model
  2. aAccording to 2011 ATS/ERS/JRS/ALAT diagnostic guidelines [24]
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Respiratory Research

ISSN: 1465-993X

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