Fig. 4
A IL-5 (white circles) and IL-13 (black squares) cytokine secretion of ILC2s in the presence of ascending concentrations of PGD2 and selected metabolites, n = 3. Values are given as mean ± SD. Nonlinear curve fit with constraints of bottom constant equal to zero and top constant equal to 100 was applied to derive EC50 and EC70. B Maximal cytokine secretion of selected metabolites compared to PGD2. The absolute concentrations of secreted cytokines were compared and normalized to 100% PGD2, n = 6. Values are given as mean ± SD. 9α,11β-PGF2: IL-5 p = 0.006, IL-13 p = 0.02, PGJ2: IL-5 p = 0.03, IL-13 p = 0.007. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001