Fig. 6

Intratracheal delivery of AAV1.Notch4 improves pulmonary hemodynamics in the hypoxic PH rats compared with negative controls. A, B The preventive and therapeutic efficacy of AAV1.Notch4 were assessed by right ventricular systolic pressure (RVSP). C Blood pressure (BP) were measured in rats treated with AAV1.Notch4 or AAV1.NC under normoxic or hypoxic condition. D RV hypertrophy was determined by the RV/(LV + S) weight ratio. E RV hypertrophy was determined by the RV/BW ratio. Data were presented as means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. One-way ANOVA followed by Tukey’s correction for post-hoc comparisons were performed for B–E. AAV adeno-associated virus, PH pulmonary hypertension, RVSP right ventricular systolic pressure, RV right ventricle, LV left ventricle, BW body weight, S septum, P prevention, T treatment