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Table 4 Subset analysis of DM-ILD with and without anti-MDA5 antibody

From: Enhanced immune complex formation in the lungs of patients with dermatomyositis

 

With MDA5 Ab

Without MDA5 Abb

P value

Number

9

9

 

Age

55 (48–66)

53 (44–63)

0.659

Sex: male

5 (56%)

1 (11%)

0.131

Clinical course: RP-ILD

7 (78%)

2 (22%)

0.057

Tissue collection method

  

0.002

 SLB

3 (33%)

8 (89%)

 

 Transplant

0 (0%)

1 (11%)

 

 Autopsy

6 (67%)

0 (0%)

 

Dx of IIMs

  

0.620

 DM

5 (56%)

7 (78%)

 

 CADM

4 (44%)

2 (22%)

 

Histological pattern

  

 < 0.001

 DAD

9 (100%)

2 (22%)

 

 NSIP

0 (0%)

6 (67%)

 

 UIP

0 (0%)

1 (11%)

 

IHC staininga

   

 C3c

0/3/4/2

(1.889 ± 0.782)

3/4/2/0

(0.889 ± 0.782)

0.022

 IgG

0/2/5/2

(2.000 ± 0.707)

0/2/7/0

(1.778 ± 0.441)

0.458

 IgA

1/6/0/2

(1.333 ± 1.000)

4/5/0/0

(0.556 ± 0.527)

0.060

 IgM

5/3/1/0

(0.556 ± 0.726)

2/7/0/0

(0.778 ± 0.441)

0.315

 MDA5

0/0/8/1

(2.111 ± 0.333)

0/1/7/1

(2.000 ± 0.500)

0.586

  1. CADM clinical amyopathic dermatomyositis; DAD diffuse alveolar damage; DM dermatomyositis; Dx diagnosis; IHC immunohistochemistry; IIMs idiopathic inflammatory myopathies; ILD interstitial lung disease; MDA5 melanoma differentiation-associated gene 5; NSIP nonspecific interstitial pneumonia; RP-ILD rapidly progressive interstitial lung disease; SLB surgical lung biopsy; UIP usual interstitial pneumonia
  2. Expression intensity score 0, negative staining; score 1, weakly positive; score 2, moderately positive; and score 3, strongly positive. Details were described in the “Methods” section
  3. aIHC staining items are indicated by intensity scores of 0/1/2/3 and mean ± SD
  4. bPatients without anti-MDA5 antibody were all positive for anti-Aminoacyl-tRNA Synthetase antibodies
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Respiratory Research

ISSN: 1465-993X

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