Fig. 10

C75 significantly reduced lung vascular leakage and attenuated lung inflammation in DIO mice during LPS-induced ALI. The lean and DIO mice were intratracheally instilled LPS or saline for 8 h. C75 was intraperitoneally administered in DIO mice 30 min before LPS instillation. a Representative lung anatomy images following Evans blue dye injection into each group of mice. b–d Evans blue dye leaking index (b), lung wet/dry (W/D) ratios (c), and BALF protein concentration (d) in each group of mice were measured. e–g The levels of TNF-α (e), IL-6 (f), and IL-1β (g) in lung homogenates in each group were detected by ELISA assay. n = 6 mice in each group. One-way ANOVA and LSD or Games–Howell posthoc analysis. Data were represented as mean ± SD