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Fig. 1 | Respiratory Research

Fig. 1

From: Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium

Fig. 1

Influence of smoke exposure on ACE2 expression. (A) Diagram of the ACE2 isoforms as decribed previously [6]. (B) Influence of smoking status (current n = 37 vs. never smokers n = 40) on counts per million reads mapped (CPM)-normalised ACE2 isoform expression in bronchial biopsies, mean ± SEM (Wilcoxon signed-rank test). Read counts corresponding to exons 1–9 and 9a-19 were calculated using the htseq-count tool of HTSeq package v.0.12.4. The number of reads mapping to exon 9a was calculated separately as reads overlapping genomic range of exon 9a – GRCh38:chrX:15,580,281 − 15,580,438. (C) Association of CPM-normalised ACE2 isoform expression with the estimated proportion of secretory cells (n = 77; Spearman test)

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Respiratory Research

ISSN: 1465-993X

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