Table 2 Clinical characteristics and laboratory parameters of patients in the non-COVID-19 and COVID-19 groups
From: Decreased level of serum NT-proCNP associates with disease severity in COVID-19
Characteristics | Non-COVID-19 (n = 35) | COVID-19 (n = 32) | p value |
|---|---|---|---|
Clinical characteristics | |||
O2 supply L/min (IQR) | 0 (0) | 0 (9)* | < 0.01 |
Fever n (%) | 18 (51) | 25 (78) | 0.04 |
GCS on admission (SD) | 15 (0) | 14.6 (2.1) | 0.31 |
Dyspnoea n (%) | 17 (49) | 19 (59) | 0.46 |
Laboratory parameters | |||
Leukocytes 103/µL (IQR) | 8.7 (4.48) | 4.8 (4.2) | < 0.01 |
Platelets 103/µL (IQR) | 230.5 (126) | 183 (69) | 0.03 |
Haemoglobin g/dL (IQR) | 12.9 (3.8) | 12.8 (4.3) | 0.63 |
CRP mg/L (IQR) | 19.5 (42.4) | 53.4 (120.2) | 0.03 |
PCT ng/mL (IQR) | 0.06 (0.13) | 0.1 (0.22) | 0.04 |
IL-6 pg/mL (IQR) | 22.7 (42.3) | 33 (95) | 0.49 |
GOT U/L (IQR) | 24.5 (14) | 41.5 (23) | < 0.01 |
GPT U/L (IQR) | 21 (16) | 26.5 (20) | 0.03 |
GGT U/L (IQR) | 34 (67) | 62 (89) | 0.09 |
LDH U/L (IQR) | 216 (70) | 332.5 (228) | < 0.01 |
Bilirubin mg/dL (IQR) | 0.5 (0.4) | 0.4 (0.25) | 0.28 |
Creatinine mg/dL (IQR) | 0.87 (0.43) | 0.94 (0.52) | 0.53 |
Ca2+ mmol/L (SD) | 1.22 (0.04) | 1.16 (0.07) | < 0.01 |
Na+ mmol/L (SD) | 138.5 (3.57) | 137.9 (4.5) | 0.59 |
K+ mmol/L (SD) | 4.4 (0.56) | 4.2 (0.67) | 0.18 |
CK U/L (IQR) | 70 (58) | 60 (95) | 0.99 |
Troponin T ng/L (IQR) | 8.2 (26.8) | 8.25 (6.7) | 0.83 |
NT-proBNP pg/mL (IQR) | 242 (1571) | 184.5 (862) | 0.57 |
Myoglobin ng/mL (IQR) | 49 (34) | 56 (54) | 0.39 |
D-dimer mg/L (IQR) | 0.55 (1.13) | 1.2 (1.5) | 0.07 |
vWF activity % (IQR) | 187.5 (155) | 288.9 (102) | < 0.01 |
vWF antigen % (IQR) | 195.5 (160) | 284.5 (168) | < 0.01 |
Fibrinogen mg/dL (IQR) | 368.5 (118.5) | 387 (395) | 0.73 |
CNP and furin measurements | |||
NT-proCNP pmol/L (IQR) | 24.8 (18.54) | 14.9 (15.97) | < 0.01 |
Furin pg/mL (IQR) | 10 (5.9) | 10 (91.6) | 0.09 |
Endpoints | |||
Primary composite endpoint | 1 (2.9) | 13 (40.6) | < 0.01 |
Need for mechanical ventilation and/or ECMO n (%) | 1 (2.9) | 12 (38) | < 0.01 |
Death n (%) | 1 (2.9) | 7 (21.9) | 0.02 |