Table 1 Baseline demographics of patients overall, and stratified by prompt or delayed initiation of FF/UMEC/VI
|  | Total (N = 1599) | Prompt (0–30 days) (N = 393) | Delayed (31–180 days) (N = 1206) |
|---|---|---|---|
Age at index (years) | Â | Â | Â |
 Mean (SD) | 69.8 (10.3) | 69.5 (9.8) | 69.9 (10.5) |
Sex, n (%) | Â | Â | Â |
 Male | 847 (53.0) | 218 (55.5) | 629 (52.2) |
Ethnicity, n (%) | Â | Â | Â |
 White | 1520 (95.1) | 376 (95.7) | 1144 (94.9) |
 Other | 22 (1.4) | 5 (1.3) | 17 (1.4) |
 Unknown | 57 (3.6) | 12 (3.1) | 45 (3.7) |
Smoking status, n (%) | Â | Â | Â |
 Current smoker | 811 (50.7) | 216 (55.0) | 595 (49.3) |
 Former smoker | 788 (49.3) | 177 (45.0) | 611 (50.7) |
BMI (kg/m2) | n = 1429 | n = 354 | n = 1075 |
 Mean (SD) | 27.3 (6.3) | 27.2 (6.4) | 27.40 (6.3) |
FEV1/FVC ratio | n = 973 | n = 251 | n = 722 |
 Mean (SD) | 56.3 (14.5) | 55.1 (13.7) | 56.72 (14.8) |
FEV1% predicted | n = 1289 | n = 326 | n = 963 |
 Mean (SD) | 55.7 (19.5) | 53.5 (18.7) | 56.41 (19.7) |
MRC Dyspnea Scale score, n (%) | Â | Â | Â |
 Grade 1 | 114 (7.1) | 26 (6.6) | 88 (7.3) |
 Grade 2 | 447 (28.0) | 110 (28.0) | 337 (27.9) |
 Grade 3 | 491 (30.7) | 118 (30.0) | 373 (30.9) |
 Grade 4 | 322 (20.1) | 97 (24.7) | 225 (18.7) |
 Grade 5 | 66 (4.1) | 15 (3.8) | 51 (4.2) |
 Unknown | 159 (9.9) | 27 (6.9) | 132 (11.0) |
Comorbidities*, n (%) | Â | Â | Â |
 Depression | 738 (46.2) | 190 (48.4) | 548 (45.4) |
 Rheumatoid/osteo arthritis | 612 (38.3) | 136 (34.6) | 476 (39.5) |
 Anxiety | 505 (31.6) | 115 (29.3) | 390 (32.3) |
 Gastroesophageal reflux disease | 450 (28.1) | 114 (29.0) | 336 (27.9) |
 Diabetes | 359 (22.5) | 88 (22.4) | 271 (22.5) |
 Stroke | 194 (12.1) | 42 (10.7) | 152 (12.6) |
 Acute myocardial infarction | 186 (11.6) | 45 (11.5) | 141 (11.7) |
 Congestive heart failure | 172 (10.8) | 52 (13.2) | 120 (10.0) |
 Dementia/cognitive impairment | 170 (10.6) | 39 (9.9) | 131 (10.9) |
 Bronchiectasis | 113 (7.1) | 30 (7.6) | 83 (6.9) |
 Lung cancer | 23 (1.4) | 5 (1.3) | 18 (1.5) |