Skip to main content
Fig. 2 | Respiratory Research

Fig. 2

From: Usefulness of FAPα assessment in bronchoalveolar lavage as a marker of fibrogenesis: results of a preclinical study and first report in patients with idiopathic pulmonary fibrosis

Fig. 2

The pulmonary uptake of [18F]FAPI-74 is a marker of fibrogenesis in bleomycin-treated mice: A-B. Time-course of the [18F]FAPI-74 lung uptake measured between 60 and 70 min after the radiotracer injection at day 3 (D3), day 10 (D10), day 16 (D16) and day 28 (D28) after instillation in bleomycin-treated (black column bars) and control mice (white column bars). C. Evaluation of lung fibrosis at D3, D10, D16 and D28 using the Ashcroft modified scale. Data are presented as mean with standard deviation and statistical analysis was performed using Two-Way ANOVA followed by Bonferroni’s correction test for multiple comparisons. D-E. Evaluation of the inflammatory response based on the RNA expression of MCP-1 and IL-6, normalized by GAPDH. Data are presented as median with interquartile range and statistical analysis was performed using Two-Way ANOVA followed by Bonferroni correction test for multiple comparisons. Controls n = 4–10; bleomycin-treated: n = 6–15. *: p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us