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Fig. 4 | Respiratory Research

Fig. 4

From: Usefulness of FAPα assessment in bronchoalveolar lavage as a marker of fibrogenesis: results of a preclinical study and first report in patients with idiopathic pulmonary fibrosis

Fig. 4

Effect of an antifibrotic treatment on FAPα levels in BALFs from bleomycin-treated mice: (A) Measurement of the concentration of FAPα in BALFs from control mice (CTRL) and bleomycin-treated mice (0.01U/mouse) eight days after instillation. Bleomycin-treated mice received nintedanib (NTD) or the vehicle orally once a day. Data are presented as mean with standard deviation and statistical analysis was performed using One-Way ANOVA followed by Holm-Sidak’s post-hoc test. (B) Evaluation of the Ashcroft modified scale. (C) Correlation of Ashcroft modified scale and FAPα concentration in BALF (C). Data are presented as median with interquartile range and statistic analysis was performed using Kruskal-Wallis test followed by Dunn’s post-hoc test. The r represents the Spearman r for non-parametric correlation. CTRL (0,9%NaCl) : n = 4; nintedanib: n = 5; vehicle (1% Tween 80): n = 5. *: p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001

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Respiratory Research

ISSN: 1465-993X

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