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Fig. 5 | Respiratory Research

Fig. 5

From: Usefulness of FAPα assessment in bronchoalveolar lavage as a marker of fibrogenesis: results of a preclinical study and first report in patients with idiopathic pulmonary fibrosis

Fig. 5

FAPα concentration in BALF is higher in IPF patients: (A) Measurement of FAPα in BALF from patients with idiopathic pulmonary fibrosis (IPF) compared to controls (CTRL). Red points correspond to patients with an acute exacerbation. Data are presented as median with interquartile range and statistical analysis was performed using Mann-Whitney test. CTRL: n = 19 and IPF patients: n = 29. (B) Comparison of the FAPα BAL concentration between stable and IPF patients with a progressive phenotype (progressor) and controls (CTRL). Data are presented as median with interquartile range and statistical analysis was performed using Kruskal-Wallis test followed by Dunn’s post-hoc test. CTRL: n = 19; stable IPF patients n = 10; progressor IPF patients n = 7. (C) ROC analysis of the risk of progression based on FAPα BALF concentration. (D) Kaplan-Meier curves showing the progression free survival of IPF patients with lower or higher FAPα BALF concentration of 192.5 pg/mL. Progression was defined as having either disease progression as defined in the 2022 guidelines, a lung transplantation or death. *: p < 0.05; ****: p < 0.0001

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Respiratory Research

ISSN: 1465-993X

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