Fig. 6
From: Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer
Knockdown of CREB1 confers sensitivity to IKE and could be rescued by SCD in vivo. A Tumors were resected after 4 weeks. B Tumor volumes were measured weekly. C The tumor weight of each group was determined after 4 weeks. D Representative images of immunohistochemistry staining of 4-HNE, p-CREB1, and SCD from different groups. 4-HNE, 4-Hydroxynonenal. Data were analyzed by two-way ANOVA and were presented by mean ± SD from six biological replicates. ns, not significant; *, p < 0.05; **, p < 0.01; ***, p < 0.001