Fig. 5
From: Amitriptyline inhibits bronchoconstriction and directly promotes dilatation of the airways
Amitriptyline causes bronchodilatation in obstructive lung disease. A Pre-contraction of rat PCLS with methacholine, following dilatation with IBMX/salbutamol, amitriptyline and combination therapy. Minimal airway area. n = 6 in all groups. B Re-contraction of dilated PCLS with rising concentrations of methacholine. Airway area after dilatation and following stimulations with methacholine. n = 4 in all groups. All graphs represent means ± SEM; *p < 0.05, **p < 0.01, ***p < 0.001