Fig. 1
From: Inhibition of SARS-CoV-2 infection in human airway epithelium with a xeno-nucleic acid aptamer
Interaction between FANA-R8-9 and SARS-CoV-2 spike-bearing pseudovirus particles. A Aptamer-mediated inhibition of pseudovirus particle uptake in Vero E6 cells. Data shown represent the mean of 6–12 replicates per condition, combined across three (Fixed DNA; FANA-IN-1.1), four (Fixed FANA), or six (FANA-R8-9) experiments ± SEM. B Cartoon schematic of the experimental workflow utilized to generate the data in panel C. Radiolabeled FANA-R8-9 (pink); unlabeled DNA competitor (green). RT = room temperature. Created with BioRender.com. C Quantification of FANA-R8-9 (or control) aptamer bound to increasing amounts of SARS-CoV-2 spike-bearing pseudovirus particles. Data shown represent the mean of single replicates per condition, combined across two (Fixed FANA; FANA-IN-1.1; Fixed DNA) or three (FANA-R8-9) experiments ± SEM