Table 3 Univariable and multivariable analyses with logistic regression models for variables associated with hematologic malignant pleural effusions in pleural effusion with ADA ≥ 40 IU/L

Age ≥ 65 years

0.56 (0.34–0.91)

Pleural effusion

 ADA, IU/L

  40 ≤ ADA < 70

Reference

Reference

  70 ≤ ADA < 150

1.03 (0.61–1.73)

0.91 (0.48–1.73)

  ADA ≥ 150

3.57 (2.02–6.30)

13.21 (5.67–30.79)

 Lymphocytes, %

  Lymphocytes < 35

Reference

  35 ≤ Lymphocytes < 70

0.96 (0.55–1.66)

  Lymphocytes ≥ 70

0.52 (0.27–1.01)

 PMN < 50%

22.36 (7.02–71.22)

42.02 (11.78–149.92)

 Eosinophils ≥ 10%

0.97 (0.30–3.22)

 pH < 7.2

0.79 (0.34–1.86)

 Glucose < 60 mg/dL

0.60 (0.37–0.98)

 Protein ≥ 2/3× serum ULN

0.16 (0.06–0.43)

 LD/ADA < 18

1.35 (0.87–2.11)

Serum

 WBC ≥ 10,000/µL

0.56 (0.33–0.94)

 Platelets < 150,000/µL

5.26 (3.30–8.41)

5.92 (3.28–10.68)

 Protein < serum LLN

0.29 (0.18–0.47)

 LD ≥ 2× serum ULN

6.35 (2.72–14.80)

3.88 (1.56–9.62)