Fig. 5

Significance of IA score in risk stratification of stage IA lung adenocarcinoma. A OS (left) and DFS (right) curves between two risk types of stage IA LUAD patients divided by median of IA score (IA H and IA L; IA score is a prognostic protective score) and stage IB-II LUAD patients; B volcano plots for DEGs between IA L and IA H (left), between IA L and IB-II (middle), and between IA-H and IB-II (right); C Down (left) and Up (right) DEGs between IA L and IA H, between IA L and IB-II, and between IA-H and IB-II; D similarities between query signature (IA H vs. IA L) and touchstone signatures (compounds inhibiting certain pathways in lung cancer cell lines) in Connective Map database; E OS (left) and DSS (right) curves among IA1, IA2, IA3 and T1N1 LUAD patients in SEER database; F OS (left) and DSS (right) curves among IA1, IA2, IA3 and T2aN0 LUAD patients in SEER database; G OS (left) and DFS (right) curves between two risk types of stage IA LUAD patients divided by median of IA score (N0 H and N0 L) and stage T1N1 LUAD patients; H OS (left) and DFS (right) curves between two risk types of stage IA LUAD patients divided by median of IA score (T1 H and T1 L) and stage T2, T3–4 LUAD patients. LUAD lung adenocarcinoma, OS overall survival, DFS disease-free survival, DSS disease-specific survival, DEGs differentially expressed genes, SEER Surveillance Epidemiology and End Results