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Table 3 Linear regression of the association between SAF and lung function parameters in total population

From: The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study

FEV1 predicted%

(N = 2577)

Unstandardized coefficient β (95% CI)

P-value

P for Interaction

SAF*smoking1

P for Interaction

SAF*COPD2

Model 1

-5.612 (-7.145 - -4.080)

< 0.001

Ex 0.004

0.006

Model 2

-4.544 (-6.037 - -3.052)

< 0.001

Model 3

-3.384 (-4.877 - -1.892)

< 0.001

DLCOc(N = 2437)

 

Model 1

− 0.326 (-0.439 - − 0.213)

< 0.001

Ex < 0.001

< 0.001

Model 2

− 0.299 (-0.414 - − 0.185)

< 0.001

Model 3

− 0.212 (-0.327 - − 0.097)

< 0.001

DLCOc/VA(N = 2437)

 

Model 1

− 0.027 (-0.046 - − 0.007)

0.007

Ex 0.03

< 0.001

Model 2

− 0.031 (-0.050 − 0.012)

0.002

Model 3

− 0.015 (-0.034 − 0.004)

0.116

  1. Model 1: Age, sex, Rotterdam Study subcohort adjusted
  2. Model 2: Model 1 + diabetes, physical activity, eGFR, BMI, oral and inhaled corticosteroids prescription adjusted
  3. Model 3: Model 2 + smoking status adjusted
  4. 1P values for interaction were derived from the model with interaction terms of SAF and smoking status
  5. 2P values for interaction were derived from the model with interaction terms of SAF and COPD diagnosis
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Respiratory Research

ISSN: 1465-993X

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