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Table 5 Cox proportional analyses for sRAGE, EN-RAGE and COPD incidence and prevalence

From: The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study

 

COPD incidence

sRAGE n/N = 151/1114,

EN-RAGE n/N = 151/1110

COPD prevalence

sRAGE and EN-RAGE n/N = 83/1192

sRAGE

HR (95% CI)

P-value

OR (95% CI)

P-value

Model 1

1.051 (0.745 -1.484)

0.776

0.597(0.377 - 0.947)

0.028

Model 2

1.028 (0.720 -1.467)

0.878

0.575(0.354 - 0.931)

0.025

EN-RAGE

HR (95%CI)

P-value

OR (95% CI)

P-value

Model 1

1.066 (0.766 - 1.482)

0.705

1.735(1.124 - 2.678)

0.013

Model 2

1.037 (0.739 - 1.455)

0.834

1.778(1.142 - 2.768)

0.011

  1. *sRAGE and EN-RAGE was used as Ln-transformed value in the models
  2. Model 1: Age, sex adjusted
  3. Model 2: Model 1 + diabetes, eGFR, BMI and smoking status adjusted