Table 6 Linear regression of the association between SAF and lung function parameters stratified by COPD diagnosis
From: The AGE-RAGE axis associates with chronic pulmonary diseases and smoking in the Rotterdam study
FEV1%predicted N = 2577 | No COPD (N = 1964) | COPD (N = 613) | ||
|---|---|---|---|---|
|  | Unstandardized coefficient β (95% CI) | P-value | Unstandardized coefficient β (95% CI) | P-value |
Model 1 | -3.115(-4.723 - -1.508) | < 0.001 | -8.876(-11.674 - -6.059) | < 0.001 |
Model 2 | -2.177(-3.756 - − 0.598) | 0.007 | -7.278(-9.972 - -4.585) | < 0.001 |
Model 3 | -1.712(-3.306 - − 0.118) | 0.035 | -6.362(-9.055 - -3.670) | < 0.001 |
DLCOc N = 2356 | No COPD (N = 2033) | COPD (N = 323) | ||
|  | Unstandardized coefficient β (95% CI) | P-value | Unstandardized coefficient β (95% CI) | P-value |
Model 1 | − 0.189(-0.308 - − 0.071) | 0.002 | − 0.675(-1.038 - − 0.312) | <0.001 |
Model 2 | − 0.171(-0.291 - 0.051) | 0.005 | − 0.643(-1.009 - − 0.278) | <0.001 |
Model 3 | − 0.112(-0.232 - 0.009) | 0.070 | − 0.550(-0.909 - − 0.191) | 0.003 |
DLCOc/VAN = 2356 | No COPD (N = 2033) | COPD (N = 323) | ||
|  | Unstandardized coefficient β (95% CI) | P-value | Unstandardized coefficient β (95% CI) | P-value |
Model 1 | − 0.002(-0.023 - 0.019) | 0.849 | − 0.075(-0.128 - − 0.023) | 0.005 |
Model 2 | − 0.010(-0.031 - 0.011) | 0.343 | − 0.074(-0.126 - − 0.022) | 0.005 |
Model 3 | 0.001(-0.020 - 0.021) | 0.939 | − 0.065(-0.117 - − 0.014) | 0.013 |