Association of musculoskeletal involvement with lung function and mortality in patients with idiopathic pulmonary fibrosis

Table 4 High BMI, low FFMI, frailty category and sarcopenia as predictors of pulmonary function adjusted for age and gender

	High BMI		Low FFMI		Prefrail		Frail		Sarcopenia
	β	p-value	β	p-value	β	p-value	β	p-value	β	p-value
FVC	0.5	0.005	− 0.2	0.4	− 0.4	0.04	− 0.7	< 0.001	− 0.5	0.07
FVC%	13.2	0.01	− 2.5	0.6	− 11.9	0.02	− 19.9	< 0.001	− 9.1	0.16
DLCO	4.1	< 0.001	− 2.5	0.02	− 1.1	0.04	− 3.3	0.01	− 4.2	< 0.001
DLCO %	13.4	0.006	− 7.2	0.1	− 2.6	0.6	− 11.4	0.02	− 15.1	0.01
Six Minute walk distance	− 8.8	0.93	− 15	0.9	− 141.4	0.1	− 211.9	0.04	− 123.9	0.29
SGRQ	− 7.1	0.17	2.6	0.6	11.4	0.01	23.4	< 0.001	2.3	0.7
Absolute change in FVC% at 6 months	− 0.1	0.61	3.1	0.3	− 2.7	0.4	− 7.1	0.04	2.8	0.49
Absolute Change in FVC% at 12 months	2.5	0.05	2.4	0.4	− 0.1	1	1.3	0.65	− 2	0.61

BMI: Body Mass Index; FVC: Forced Vital Capacity; DLCO: Diffusion Capacity of Lung for Carbon Monoxide; SGRQ: St. George's Respiratory Questionnaire; FFMI: Fat-Free Mass Index. β is the degree of change in outcome variable for presence of high BMI, low FFMI, Frailty, Sarcopenia

ISSN: 1465-993X